Evaluating troponin elevation in patients with chronic kidney disease and suspected acute coronary syndrome

Article Figures & Data

TABLE 1

Troponin cutoffs for acute coronary syndrome in patients with chronic kidney disease

Authors and year	Troponin fragment Manufacturer	Manufacturer	Manufacturer’s upper reference limit	Authors’ suggested cut-off	Sensitivity	Specificity
Chenevier-Gobeaux et al,¹⁵ 2013	T	Roche	14 ng/L	35.8 ng/L (AMI)	94%	86%
Chenevier-Gobeaux et al,¹⁵ 2013	T	Roche	14 ng/L	43.2 ng/L (NSTEMI)	92%	88%
Kraus et al,¹⁶ 2018	I	Abbott	30 ng/L	54 ng/L	82%	90%
Kraus et al,¹⁶ 2018	T	Roche	14 ng/L	50 ng/L	66%	80%
Twerenbold et al,¹⁷ 2015	T	Roche	14 ng/L	29.5 ng/L	84%	79%
	I	Abbott	26.2 ng/L	29.4 ng/L	76%	85%
	I	Siemens	9 ng/L	32 ng/L	82%	83%
	I	Beckman-Coulter	9.2 ng/L	25.9 ng/L	81%	83%
Yang et al,¹⁸ 2017	T	Roche	14 ng/L	129 ng/L (CKD 3–5)	75.2%	83.2%
				99.55 ng/L (CKD 3)	82.8%	82.1%
				129.45 ng/L (CKD 4)	73.2%	85.4%
				105.5 ng/L (CKD 5)	81%	88.9%
				149.35 ng/L (HD)	79.2%	81.9%
Twerenbold et al,¹⁹ 2018	T	Roche	14 ng/L	52 ng/L or 1-hour change ≥ 5 ng/L	100%	88.7%
Twerenbold et al,¹⁹ 2018	I	Abbott	26.2 ng/L	52 ng/L or 1-hour change ≥ 6 ng/L	98.6%	84.4%
Sittichanbuncha et al,²⁰ 2015	T	Roche	14 ng/L	41 ng/L	67% (CKD 3)	79% (CKD 3)
Sittichanbuncha et al,²⁰ 2015	T	Roche	14 ng/L	41 ng/L	71% (CKD 4–5)	56% (CKD 4–5)
Lim and Lee,²¹ 2020	I	Siemens	47.34 ng/L	75 ng/L (HD)	93.3%	60.76%
Lim and Lee,²¹ 2020	I	Siemens	47.34 ng/L	144 ng/L (PD)	100%	83.1%

AMI = acute myocardial infarction; NSTEMI = non-ST-elevation myocardial infarction; CKD = chronic kidney disease and stage; HD = hemodialysis; PD = peritoneal dialysis
Data from information in reference 4.