ERAAs for menopause treatment: Welcome the ‘designer estrogens’

Article Figures & Data

TABLE 1

Designer estrogens and their uses

Agent	Approved uses	Other possible benefits	Adverse effects
Tamoxifen	To treat metastatic breast cancer and ductal carcinoma in situ To reduce the risk of estrogen receptor-positive breast cancer in women at high risk	Positive effect on bone Positive effect on cardiovascular risk	Venous thromboembolism Uterine neoplasia Vasomotor symptoms
Raloxifene	To prevent and treat osteoporosis To reduce the risk of invasive estrogen receptor-positive breast cancer in postmenopausal women	Reduction in breast cancer risk	Venous thromboembolism Stroke
Ospemifene	To treat genitourinary syndrome of menopause	Positive effect on bone	Venous thromboembolism
Conjugated estrogen-bazedoxifene	In women with a uterus: to prevent osteoporosis and treat vasomotor symptoms of menopause	Positive effects on uterus, genitourinary syndrome of menopause	Venous thromboembolism