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Review

Coronary microvascular dysfunction: Considerations for diagnosis and treatment

Benita Tjoe, MD, Lili Barsky, MD, Janet Wei, MD, Bruce Samuels, MD, Babak Azarbal, MD, C. Noel Bairey Merz, MD and Chrisandra Shufelt, MD, MS
Cleveland Clinic Journal of Medicine October 2021, 88 (10) 561-571; DOI: https://doi.org/10.3949/ccjm.88a.20140
Benita Tjoe
Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
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Lili Barsky
Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
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Janet Wei
Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) ; Investigator, Women’s Ischemia Syndrome Evaluation (WISE)
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Bruce Samuels
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
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Babak Azarbal
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
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C. Noel Bairey Merz
Director, Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) ; Investigator, Women’s Ischemia Syndrome Evaluation (WISE)
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Chrisandra Shufelt
Associate Director, Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) ; Investigator, Women’s Ischemia Syndrome Evaluation (WISE)
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  • For correspondence: [email protected]
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Article Information

vol. 88 no. 10 561-571
DOI 
https://doi.org/10.3949/ccjm.88a.20140
PubMed 
34598921

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online October 1, 2021.

Copyright & Usage 
Copyright © 2021 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Benita Tjoe, MD*
  1. Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
  1. Lili Barsky, MD*
  1. Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
  1. Janet Wei, MD
  1. Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) NCT03417388; Investigator, Women’s Ischemia Syndrome Evaluation (WISE) NCT00000554
  1. Bruce Samuels, MD
  1. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
  1. Babak Azarbal, MD
  1. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
  1. C. Noel Bairey Merz, MD
  1. Director, Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) NCT03417388; Investigator, Women’s Ischemia Syndrome Evaluation (WISE) NCT00000554
  1. Chrisandra Shufelt, MD, MS⇑
  1. Associate Director, Barbra Streisand Women’s Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA; Investigator, Women’s Ischemia Trial to Reduce Events in Nonobstructive CAD (WARRIOR) NCT03417388; Investigator, Women’s Ischemia Syndrome Evaluation (WISE) NCT00000554
  1. Address:
    Chrisandra Shufelt, MD, MS, Barbra Streisand Women’s Heart Center, Cedars-Sinai Smidt Heart Institute, 8631 W. Third Street, Suite 740, Los Angeles, CA, 90048; Chrisandra.Shufelt{at}cshs.org
  1. ↵* These authors contributed equally to this work.

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Cleveland Clinic Journal of Medicine: 88 (10)
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Coronary microvascular dysfunction: Considerations for diagnosis and treatment
Benita Tjoe, Lili Barsky, Janet Wei, Bruce Samuels, Babak Azarbal, C. Noel Bairey Merz, Chrisandra Shufelt
Cleveland Clinic Journal of Medicine Oct 2021, 88 (10) 561-571; DOI: 10.3949/ccjm.88a.20140

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Coronary microvascular dysfunction: Considerations for diagnosis and treatment
Benita Tjoe, Lili Barsky, Janet Wei, Bruce Samuels, Babak Azarbal, C. Noel Bairey Merz, Chrisandra Shufelt
Cleveland Clinic Journal of Medicine Oct 2021, 88 (10) 561-571; DOI: 10.3949/ccjm.88a.20140
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Jump to section

  • Article
    • ABSTRACT
    • TINY VESSELS, BIG EFFECTS
    • RISK FACTORS AND CLINICAL PRESENTATION OF MICROVASCULAR DYSFUNCTION
    • CORONARY FUNCTION TESTING
    • OTHER DIAGNOSTIC APPROACHES
    • DRUG AND NONDRUG THERAPIES
    • KNOWLEDGE GAPS REMAIN
    • FUTURE DIRECTIONS
    • HOPE FOR STRONG GUIDELINES LIES IN ONGOING CLINICAL TRIALS
    • DISCLOSURES
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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