Table of Contents
From the Editor
- Born again: The many lives of metformin
Repurposing old drugs for new indications is not a new drug-development strategy.
The Clinical Picture
- Petaloid dermatosis affecting the scalp and genitalia
The patient had seen no improvement with a 2-week course of terbinafine cream.
- Cutaneous metastasis from gastric carcinoma
The patient presented with asymptomatic nodules and alopecia of the scalp 3 years after treatment for gastric adenocarcinoma.
- Persistent rectal pain leading to diffuse pustules
The authors relate the workup of a 34-year-old patient with a history of syphilis and human immunodeficiency virus.
1-Minute Consult
- If a patient has cirrhosis, should I correct coagulation abnormalities before a minor invasive procedure?
Hemostatic abnormalities in cirrhosis can include thrombocytopenia, prolonged prothrombin time, prolonged activated partial thromboplastin time, elevated international normalized ratio, and decreased fibrinogen.
- Should I consider metformin therapy for weight loss in patients with obesity but without diabetes?
The authors appraise the evidence to date for weight loss with metformin in this patient population.
When should pharmacologic therapies be used for uremic pericarditis?If symptoms return or fail to improve with renal replacement therapy, drug therapy may be considered.
Current Drug Therapy
- A practical guide for buprenorphine initiation in the primary care setting
The authors review changes in prescribing laws and outline buprenorphine induction protocols that can be adopted in the primary care setting.
Review
- Mpox: Keep it on the differential
During its current global outbreak, mpox has exhibited novel features that clinicians should be aware of to aid recognition.
