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Review

Severe megaloblastic anemia: Vitamin deficiency and other causes

Daniel S. Socha, MD, Sherwin I. DeSouza, MD, Aron Flagg, MD, Mikkael Sekeres, MD, MS and Heesun J. Rogers, MD, PhD
Cleveland Clinic Journal of Medicine March 2020, 87 (3) 153-164; DOI: https://doi.org/10.3949/ccjm.87a.19072
Daniel S. Socha
Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic
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Sherwin I. DeSouza
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic
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Aron Flagg
Department of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, CT
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Mikkael Sekeres
Department of Hematology and Medical Oncology and Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve, Cleveland, OH
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Heesun J. Rogers
Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic
Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Article Information

vol. 87 no. 3 153-164
DOI 
https://doi.org/10.3949/ccjm.87a.19072
PubMed 
32127439

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online March 3, 2020.

Copyright & Usage 
Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Daniel S. Socha, MD
  1. Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic
  1. Sherwin I. DeSouza, MD
  1. Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic
  1. Aron Flagg, MD
  1. Department of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, CT
  1. Mikkael Sekeres, MD, MS
  1. Department of Hematology and Medical Oncology and Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
  2. Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve, Cleveland, OH
  1. Heesun J. Rogers, MD, PhD⇑
  1. Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic
  2. Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Address: Heesun J. Rogers, MD, PhD, Department of Laboratory Medicine, L-30, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; rogersj5{at}ccf.org
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Cleveland Clinic Journal of Medicine: 87 (3)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 3
1 Mar 2020
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Severe megaloblastic anemia: Vitamin deficiency and other causes
Daniel S. Socha, Sherwin I. DeSouza, Aron Flagg, Mikkael Sekeres, Heesun J. Rogers
Cleveland Clinic Journal of Medicine Mar 2020, 87 (3) 153-164; DOI: 10.3949/ccjm.87a.19072

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Severe megaloblastic anemia: Vitamin deficiency and other causes
Daniel S. Socha, Sherwin I. DeSouza, Aron Flagg, Mikkael Sekeres, Heesun J. Rogers
Cleveland Clinic Journal of Medicine Mar 2020, 87 (3) 153-164; DOI: 10.3949/ccjm.87a.19072
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Jump to section

  • Article
    • ABSTRACT
    • MEGALOBLASTIC ANEMIA OVERVIEW
    • FOLATE DEFICIENCY
    • VITAMIN B12 DEFICIENCY
    • FOLATE AND VITAMIN B12 METABOLISM ARE INTERTWINED
    • DRUG EFFECTS
    • CLINICAL FEATURES
    • INITIAL EVALUATION
    • SPECIAL TESTING
    • DIFFERENTIAL DIAGNOSIS
    • TREAT UNDERLYING PROBLEM
    • FOLATE SUPPLEMENTATION
    • VITAMIN B12 SUPPLEMENTATION
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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