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Review

Pharmacogenomics: An evolving clinical tool for precision medicine

Jennifer K. Hockings, PharmD, PhD, Amy L. Pasternak, PharmD, Angelika L. Erwin, MD, PhD, Neil T. Mason, MBA, Charis Eng, MD, PhD and J. Kevin Hicks, PharmD, PhD
Cleveland Clinic Journal of Medicine February 2020, 87 (2) 91-99; DOI: https://doi.org/10.3949/ccjm.87a.19073
Jennifer K. Hockings
Department of Pharmacy, Cleveland Clinic; Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care
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  • For correspondence: [email protected]
Amy L. Pasternak
Clinical Assistant Professor, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan; Department of Pharmacy, Michigan Medicine, Ann Arbor, MI
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Angelika L. Erwin
Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
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Neil T. Mason
Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
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Charis Eng
Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Professor, Department of Genetics and Genomic Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
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J. Kevin Hicks
Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
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Article Information

vol. 87 no. 2 91-99
DOI 
https://doi.org/10.3949/ccjm.87a.19073
PubMed 
32015062

Published By 
Cleveland Clinic Journal of Medicine
Print ISSN 
0891-1150
Online ISSN 
1939-2869
History 
  • Published online February 3, 2020.

Copyright & Usage 
Copyright © 2020 The Cleveland Clinic Foundation. All Rights Reserved.

Author Information

  1. Jennifer K. Hockings, PharmD, PhD⇑
  1. Department of Pharmacy, Cleveland Clinic; Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care
  1. Address: Jennifer Hockings, PharmD, PhD, Department of Pharmacy, JJN1, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195; hockinc{at}ccf.org
  1. Amy L. Pasternak, PharmD
  1. Clinical Assistant Professor, Department of Clinical Pharmacy, College of Pharmacy, University of Michigan; Department of Pharmacy, Michigan Medicine, Ann Arbor, MI
  1. Angelika L. Erwin, MD, PhD
  1. Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
  1. Neil T. Mason, MBA
  1. Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
  1. Charis Eng, MD, PhD
  1. Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Professor, Department of Genetics and Genomic Sciences, Case Western Reserve University School of Medicine, Cleveland, OH
  1. J. Kevin Hicks, PharmD, PhD
  1. Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care; Department of Individualized Cancer Management, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

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Cleveland Clinic Journal of Medicine: 87 (2)
Cleveland Clinic Journal of Medicine
Vol. 87, Issue 2
1 Feb 2020
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Pharmacogenomics: An evolving clinical tool for precision medicine
Jennifer K. Hockings, Amy L. Pasternak, Angelika L. Erwin, Neil T. Mason, Charis Eng, J. Kevin Hicks
Cleveland Clinic Journal of Medicine Feb 2020, 87 (2) 91-99; DOI: 10.3949/ccjm.87a.19073

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Pharmacogenomics: An evolving clinical tool for precision medicine
Jennifer K. Hockings, Amy L. Pasternak, Angelika L. Erwin, Neil T. Mason, Charis Eng, J. Kevin Hicks
Cleveland Clinic Journal of Medicine Feb 2020, 87 (2) 91-99; DOI: 10.3949/ccjm.87a.19073
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Jump to section

  • Article
    • ABSTRACT
    • WHAT ARE PHARMACOGENES?
    • CLINICAL UTILITY OF PHARMACOGENOMICS
    • OPIOIDS AND CYP2D6
    • ANTIDEPRESSANTS AND CYP2D6, CYP2C19, SLC6A4, HTR2A, AND HTR2C
    • CLOPIDOGREL AND CYP2C19
    • OTHER CLINICAL CONSIDERATIONS
    • ADDRESSING CHALLENGES TO PHARMACOGENOMIC TESTING
    • IS PHARMACOGENOMIC TESTING COST-EFFECTIVE?
    • DIRECT-TO-CONSUMER TESTING
    • EDUCATION AND INFRASTRUCTURE NEEDED
    • DEVELOPING PHARMACOGENOMIC SERVICES
    • POISED TO IMPROVE CARE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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