Drug Therapy
- Born again: The many lives of metformin
Repurposing old drugs for new indications is not a new drug-development strategy.
- Should I consider metformin therapy for weight loss in patients with obesity but without diabetes?
The authors appraise the evidence to date for weight loss with metformin in this patient population.
- A practical guide for buprenorphine initiation in the primary care setting
The authors review changes in prescribing laws and outline buprenorphine induction protocols that can be adopted in the primary care setting.
- Heart failure with reduced ejection fraction: What’s new in the 2022 guideline?
Evidence-based and guideline-based medical therapies can help patients feel better, stay out of the hospital, live longer, and potentially improve left ventricular function.
Resistant hypertension: A stepwise approachThe authors review the definition and prevalence of resistant hypertension and its diagnostic workup and management, including lifestyle modifications, drugs, and experimental therapies.
- Balancing the myths of corticosteroid therapy
No class of drug has more mythical attributes, interfaces with different medical specialties, or clinical street lore than corticosteroids.
- Steroids in the acutely ill: Evolving recommendations and practice
New information has been generated with regard to what causes critical illness-related corticosteroid insufficiency, how to diagnose it, who should receive corticosteroid treatment, and what regimens to use.
- Managing stage 1 hypertension: Consider the risks, stop the progression
Guidelines on managing patients with stage 1 hypertension and a low 10-year risk of atherosclerotic cardiovascular disease.