Rheumatology

  • Collaborative musculoskeletal care: The role for chiropractors

    Samuel M. Schut, DC, Logan J. Benjamin, DC, MPH and Timothy J. Williamson, DC, MS
    • Cleveland Clinic Journal of Medicine September 2025, 92 (9) 550-554;
    • DOI: https://doi.org/10.3949/ccjm.92a.25014
    • Integrating chiropractors into multidisciplinary care settings can help support guideline-concordant care and may free up internists to see more patients with other problems.

  • Severe cutaneous reaction induced by allopurinol

    Pietro Bocchi, MD, Lorenza Terroni, MD and Corrado Pattacini, MD
    • Cleveland Clinic Journal of Medicine June 2025, 92 (6) 331-333;
    • DOI: https://doi.org/10.3949/ccjm.92a.24063
    • Three weeks after starting allopurinol for gout, an 86-year-old woman presented with a maculopapular rash and painful blistering and erosions of the oral mucosa.

  • Allopurinol hypersensitivity is rare, bad, and partially avoidable, but allopurinol can still be used effectively

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine June 2025, 92 (6) 326-328;
    • DOI: https://doi.org/10.3949/ccjm.92b.06025
    • The shadow of the 1984 Hande et al guidelines still hangs over clinical decision-making when managing allopurinol dosing in patients with gout and chronic kidney disease.

  • What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?

    Karthik Meiyappan Udayappan, MD and Christopher V. Anstine, MD
    • Cleveland Clinic Journal of Medicine May 2025, 92 (5) 273-276;
    • DOI: https://doi.org/10.3949/ccjm.92a.24052
    • Computed tomography of the patient’s chest is indicated based on the robust association between clubbing and intrathoracic malignancy.

  • All sulfa drugs are not created equal

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2025, 92 (3) 136-137;
    • DOI: https://doi.org/10.3949/ccjm.92b.03025
    • Misinformation about “sulfa allergy” can result in unnecessary avoidance of useful medications and the prescription of less effective alternatives.

  • Can my patient with a ‘sulfa allergy’ receive celecoxib or other nonantimicrobial sulfonamides?

    Nicholas B. Cline, MD, Amudha Pazhanisamy, DO and David M. Lang, MD
    • Cleveland Clinic Journal of Medicine March 2025, 92 (3) 147-151;
    • DOI: https://doi.org/10.3949/ccjm.92a.24054
    • There is no cross-reactivity between antimicrobial and nonantimicrobial sulfonamides, and patients with a history of immunoglobulin E–mediated reaction to a sulfonamide antibiotic can receive nonantimicrobial sulfonamides.

  • Sarcoidosis with diffuse purplish erythematous plaques on the hands

    Akihiro Orita, MD and Mitsuhito Ota, MD, PhD
    • Cleveland Clinic Journal of Medicine March 2025, 92 (3) 145-146;
    • DOI: https://doi.org/10.3949/ccjm.92a.24022
    • A 70-year-old woman presented in winter with a 1-month history of asymptomatic redness of the hands.

  • The causes of vascular insufficiency and Hickam vs Ockham

    Brian F. Mandell, MD, PhD
    • Cleveland Clinic Journal of Medicine December 2024, 91 (12) 713-714;
    • DOI: https://doi.org/10.3949/ccjm.91b.12024
    • Is our reflexive search for a single explanatory diagnosis always reasonable and warranted—or is it truly “just” an academic intellectual exercise?

  • A 74-year-old woman with purple toes

    Baila R. Elkin, MD and Megan McGervey, MD
    • Cleveland Clinic Journal of Medicine December 2024, 91 (12) 735-741;
    • DOI: https://doi.org/10.3949/ccjm.91a.24064
    • While the patient was undergoing treatment for livedoid vasculopathy, her toes started to become purple and she experienced persistent “stinging” pain in her feet.

  • Sorting out aortic aneurysms: A team enterprise

    Gary S. Hoffman, MD, MS, MACR
    • Cleveland Clinic Journal of Medicine October 2024, 91 (10) 635-637;
    • DOI: https://doi.org/10.3949/ccjm.91a.24040
    • Aortic aneurysms present considerable diagnostic and treatment challenges owing to their diverse causes, incomplete understanding of pathogenesis, and variations in presentation and disease course.