Rheumatology

Before you read this, I recommend that you read the interesting article in this issue by Prakash et al, part of our Symptoms to Diagnosis series.

Her medical history included gastroesophageal reflux disease and Sjögren syndrome. She had recently returned from travel to Malaysia.

The patient had received the live attenuated vaccine 1 month before presentation. He had no history of varicella infection.

A review of the presentation and diagnostic evaluation, including atypical features that may suggest an alternative diagnosis requiring a more extensive evaluation.

Our success in understanding well-defined autoimmune diseases may make us too willing to attribute yet-unexplained conditions to autoimmunity simply because they share symptoms.

Recurrent, dramatic flares are the cardinal symptom of gouty disease, but some patients exhibit tophi on physical examination or imaging—without flares or pain.

The range of adverse events is broad. Any organ can be affected, and any naturally occurring autoimmune process can be mimicked by the massive inflammation generated by checkpoint inhibition.

Clinicians have a pivotal role by providing patient education, which can affect perception, management, functional status, and quality of life.

Centralized pain syndromes are vexing for patients and clinicians. In this issue, Volcheck and colleagues present a framework for understanding chronic centralized pain and for developing an actionable treatment plan for patients.