Allergy/Immunology
- Hydroxychloroquine: An old drug with new relevance
This antimalarial drug is now approved to treat discoid lupus, systemic lupus erythematosus, and rheumatoid arthritis.
- Hyperkeratotic fissured plaques on both hands: Mechanic’s hands
This sign is seen in about 30% of patients with antisynthetase syndrome.
- Dysmorphic red blood cell formation
A 23-year-old woman presented with hematuria and dysmorphic red blood cells in the urinary sediment.
- Abdominal pain and bloody diarrhea in a 32-year-old woman
The patient also has numerous painful ulcerations on her skin and in her mouth.
Acute monocular vision loss: Don’t lose sight of the differentialAn 83-year-old man woke up one morning unable to see out of his left eye; 6 hours earlier it had been normal.
- A rose by any other name is still a rose—but why a rose?
Christopher Columbus returned from the New World with a chronic illness, now believed to have been reactive arthritis.
- Erythematous patches with keratotic annular borders on the glans penis
Reactive arthritis was diagnosed on the basis of urethritis, ocular symptoms, circinate balanitis, and sacroiliitis.
- Weight loss, fatigue, and renal failure
A 37-year-old man has gradually lost 100 lb over the past 2 years, with progressive fatigue and malaise.
- To have not and then to have: A challenging immune paradox
The immune reactivation syndrome can occur when the immune system in an immunosuppressed patient with a partially controlled indolent infection is suddenly normalized.
- Drug reaction or metastatic lung cancer?
Imaging shows nodules randomly distributed throughout both lungs, a paradoxical reaction to drug therapy.