Allergy/Immunology

  • Hyperkeratotic fissured plaques on both hands: Mechanic’s hands
    Anuradha Bishnoi, MD and Davinder Parsad, MD
    Cleveland Clinic Journal of Medicine April 2018, 85 (4) 268-269; DOI: https://doi.org/10.3949/ccjm.85a.17045

    This sign is seen in about 30% of patients with antisynthetase syndrome.

  • Dysmorphic red blood cell formation
    José Lucas Daza, MD, Marcelo De Rosa, MD and Graciela De Rosa, MD
    Cleveland Clinic Journal of Medicine January 2018, 85 (1) 12-13; DOI: https://doi.org/10.3949/ccjm.85a.17029

    A 23-year-old woman presented with hematuria and dysmorphic red blood cells in the urinary sediment.

  • Abdominal pain and bloody diarrhea in a 32-year-old woman
    Neha Agrawal, MD, Amandeep Singh, MD, Thomas Plesec, MD, David Liska, MD, Bradley Confer, DO, Jessica Philpott, MD, PhD and Florian Rieder, MD
    Cleveland Clinic Journal of Medicine November 2017, 84 (11) 847-854; DOI: https://doi.org/10.3949/ccjm.84a.16085

    The patient also has numerous painful ulcerations on her skin and in her mouth.

  • Acute monocular vision loss: Don’t lose sight of the differential
    Acute monocular vision loss: Don’t lose sight of the differential
    Justin R. Abbatemarco, MD, Rushad Patell, MD, Janet Buccola, MD and Mary Alissa Willis, MD
    Cleveland Clinic Journal of Medicine October 2017, 84 (10) 779-787; DOI: https://doi.org/10.3949/ccjm.84a.16096

    An 83-year-old man woke up one morning unable to see out of his left eye; 6 hours earlier it had been normal.

  • A rose by any other name is still a rose—but why a rose?
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine January 2017, 84 (1) 11-12; DOI: https://doi.org/10.3949/ccjm.84b.01017

    Christopher Columbus returned from the New World with a chronic illness, now believed to have been reactive arthritis.

  • Erythematous patches with keratotic annular borders on the glans penis
    Elisabeth Gómez-Moyano, MD, PhD, Inmaculada Ureña-Garnica, MD, PhD, Sara Manrique-Arija, MD, PhD and Luis Miguel Perez-Belmonte, MD, PhD
    Cleveland Clinic Journal of Medicine January 2017, 84 (1) 23-24; DOI: https://doi.org/10.3949/ccjm.84a.15145

    Reactive arthritis was diagnosed on the basis of urethritis, ocular symptoms, circinate balanitis, and sacroiliitis.

  • Weight loss, fatigue, and renal failure
    Qiwei Paulson, MD, Christopher A. Stearns, MD and Paul Nader, MD
    Cleveland Clinic Journal of Medicine August 2017, 84 (8) 601-607; DOI: https://doi.org/10.3949/ccjm.84a.16053

    A 37-year-old man has gradually lost 100 lb over the past 2 years, with progressive fatigue and malaise.

  • To have not and then to have: A challenging immune paradox
    Brian F. Mandell, MD
    Cleveland Clinic Journal of Medicine December 2017, 84 (12) 912-913; DOI: https://doi.org/10.3949/ccjm.84b.12017

    The immune reactivation syndrome can occur when the immune system in an immunosuppressed patient with a partially controlled indolent infection is suddenly normalized.

  • Drug reaction or metastatic lung cancer?
    Hiromichi Hara, MD, PhD, Hirofumi Utsumi, MD, PhD, Hiroshi Wakui, MD, PhD, Haruhiko Yanagisawa, MD, PhD, Mitsuo Hashimoto, MD, PhD and Kazuyoshi Kuwano, MD, PhD
    Cleveland Clinic Journal of Medicine December 2017, 84 (12) 914-915; DOI: https://doi.org/10.3949/ccjm.84a.17005

    Imaging shows nodules randomly distributed throughout both lungs, a paradoxical reaction to drug therapy.

  • Trust the thyroid thermostat
    Brian F. Mandell, MD, PhD
    Cleveland Clinic Journal of Medicine August 2016, 83 (8) 552-553; DOI: https://doi.org/10.3949/ccjm.83b.08016

    Why do some physicians persist in regularly following the T3 and T4 levels in addition to the TSH?

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