Oncology

  • Reincarnating autoimmunity: Immune-related adverse events as new diseases
    Pauline Funchain, MD
    Cleveland Clinic Journal of Medicine May 2023, 90 (5) 318-319; DOI: https://doi.org/10.3949/ccjm.90a.23013

    The range of adverse events is broad. Any organ can be affected, and any naturally occurring autoimmune process can be mimicked by the massive inflammation generated by checkpoint inhibition.

  • What is the rationale for the laboratory workup for suspected pheochromocytomas and paragangliomas?
    Hiba Z. Hashmi, MD, Muhammad Arslan Arif Maan, MD and Laura LaFave, MD
    Cleveland Clinic Journal of Medicine March 2023, 90 (3) 150-153; DOI: https://doi.org/10.3949/ccjm.90a.20197

    The decision to test is best guided by clinical suspicion. Test results should be interpreted with careful consideration of how the samples were collected.

  • Oral leukoplakia and oral cancer
    Takeshi Onda, DDS, PhD, Kamichika Hayashi, DDS, PhD, Akira Katakura, DDS, PhD and Masayuki Takano, DDS, PhD
    Cleveland Clinic Journal of Medicine February 2023, 90 (2) 79-80; DOI: https://doi.org/10.3949/ccjm.90a.22044

    A 53-year-old male who had smoked for 36 years was referred by his dentist for worsening vitiligo diagnosed as leukoplakia 3 years earlier.

  • A 60-year-old man with prostate cancer and embolic strokes
    Neha K. Reddy, MD, MA, Christian Scherer, DO, Samuel Kessel, MD, MBA and Alejandro Moreno, MBBS, MPH, JD, MACP
    Cleveland Clinic Journal of Medicine December 2022, 89 (12) 705-711; DOI: https://doi.org/10.3949/ccjm.89a.21079

    Step-by-step evaluation of a patient with stage IV prostate cancer and embolic stroke, but no history of heart valve disease, arrhythmia, or coagulopathy.

  • Reducing the risk of breast cancer
    Holly J. Pederson, MD, Zahraa Al-Hilli, MD and Allison W. Kurian, MD
    Cleveland Clinic Journal of Medicine November 2022, 89 (11) 643-652; DOI: https://doi.org/10.3949/ccjm.89a.21113

    Breast cancer remains the most common malignancy in US women. Reducing this burden involves identification of high-risk individuals and personalized risk management.

  • Mucinous ascites: Pseudomyxoma peritonei
    Sansrita Nepal, MD, Adam Schwertner, MD and John M. Cunningham, MD
    Cleveland Clinic Journal of Medicine September 2022, 89 (9) 491-493; DOI: https://doi.org/10.3949/ccjm.89a.21086

    A 59-year-old man presented with progressive abdominal distention that limited daily activities and oral intake. The ascitic fluid was markedly viscous and jelly-like.

  • What are the considerations in patient selection and timing of risk-reducing mastectomy?
    Holly J. Pederson, MD, Allison W. Kurian, MD, MSc and Zahraa Al Hilli, MD
    Cleveland Clinic Journal of Medicine August 2022, 89 (8) 442-444; DOI: https://doi.org/10.3949/ccjm.89a.21114

    The option of risk-reducing mastectomy is for those at highest risk, and multidisciplinary conversations setting patient expectations are critical for optimal patient outcomes.

  • Metastatic bone disease: Early referral for multidisciplinary care
    Amir Hossain Gahanbani Ardakani, BSc, MBBS, Martina Faimali, MBBS, FRCS (Tr&Orth), Lukas Nystrom, MD, Nathan Mesko, MD, Muntzer Mughal, MBChB, ChM, FRCS, Howard Ware, MBBS, FRCS (Tr&Orth) and Panagiotis Gikas, BSc, MBBS Hons, MD (Res), PhD, FRCS (Tr&Orth)
    Cleveland Clinic Journal of Medicine July 2022, 89 (7) 393-399; DOI: https://doi.org/10.3949/ccjm.89a.21062

    A lack of awareness and recognition of symptoms continues to delay referral to specialist teams. The authors provide guidance for early diagnosis and referral.

  • Pigmented lesion on nail bed: Pseudo-Hutchinson sign
    Yahya Daneshbod, MD, Majid Akrami, MD, Sara Fanaee, MD, Komeil Mirzaei Baboli, MD and Hadi Mirfazaelian, MD
    Cleveland Clinic Journal of Medicine June 2022, 89 (6) 303-304; DOI: https://doi.org/10.3949/ccjm.89a.21070

    The discoloration had been present since the patient was 14, and it had not changed in appearance.

  • Lacrimal gland involvement in a patient with sarcoidosis
    Tanmayi Pai, MD, Mohamed S. Muneer, MD, Kafayat Oyemade, Diva R. Salomao, MD, Vivek Gupta, MD and Dana Harris, MD
    Cleveland Clinic Journal of Medicine May 2022, 89 (5) 239-240; DOI: https://doi.org/10.3949/ccjm.89a.21037

    The differential diagnosis included infection, malignancy, and inflammatory disorders such as immunoglobulin G4-related disease and sarcoidosis.

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